PCOL488

This course will integrate and consolidate the basic concepts of chemistry and pharmacology that underlie drug discovery, design, and development. For selected drug classes, the course will lead students into a deeper understanding of pharmacodynamics beyond pharmacophore and target. Students will learn hands-on computational approaches that emphasize the 3-dimensional nature of drugs and their interaction with proteins to both explore and predict these interactions. In a team science setting, students will design small molecules to engage a protein target and conceptualize the synthesis and testing of these molecules along the drug discovery pipeline, including the consideration of screening approaches and ADMET hurdles. The course will use in-class work and team-based assignments, concluding in team presentations of drug discovery project pitches.

018867

Spring